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ceramide synthase
Ceramide synthases (CerS) are integral membrane proteins of the endoplasmic reticulum that catalyzes the synthesis of ceramide.
==History==
CerS were originally called Lass (''L''ongevity ''Ass''urance) genes because of their homology to the yeast protein, longevity assurance gene-1 (LAG1p), and they were later renamed due to the discovery of their biological function.
LAG1 in yeast was discovered in 1994, and named thus for the discovery that its deletion prolonged life span of'' S. cerevisiae'' by almost 50%. In the following years, it and its homologs were shown to be required for the syntheses of ceramides found in yeast. Three years previously, the mammalian gene upstream of growth and differentiation factor-1 (UOG-1) was discovered, but it wasn't until 2005 that it was defined as the first mammalian CerS, when Sujoy Lahiri and Tony Futerman from the Weizmann Institute of Science found that LASS5 is a bona fide mammalian ceramide synthase that specifically synthesizes Palmitoyl (C16) ceramide..〔
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